Evidence for spatial navigational impairments in hydrocephalus patients without spina bifida

• Published in: Brain and cognition Vol. 83; no. 1; pp. 132 - 141
• Main Authors: Buckley, Matthew G., Smith, Alastair D.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.10.2013; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Cerebrospinal fluid. Meninges. Spinal cord; Cognitive ability; Cues; Diseases of the osteoarticular system; Diseases of the spine; Female; Humans; Hydrocephalus; Hydrocephalus - physiopathology; Learning - physiology; Male; Malformations and congenital and or hereditary diseases involving bones. Joint deformations; Medical sciences; Memory - physiology; Navigation; Nervous system (semeiology, syndromes); Neurology; Neuropsychological Tests; Organic mental disorders. Neuropsychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Spatial cognition; Spinal Dysraphism - physiopathology; Young Adult; Hydrocephalus; Spatial cognition; Navigation; Human; Nervous system diseases; Diseases of the osteoarticular system; Spine disease; Experimental study; Congenital disease; Cerebral disorder; Spina bifida; Malformation; Central nervous system disease; Hydrocephaly
• ISSN: 0278-2626; 1090-2147
• DOI: 10.1016/j.bandc.2013.07.010

•Patients with hydrocephalus were examined on a variety of navigational measures.•Relative impairments of spatial cueing, route-learning, and spatial updating.•First demonstration of spatial impairments outside of the context of spina bifida. The cognitive sequelae of hydrocephalus have mostly been explored with standardised clinical tasks. The aim of the present research was determine whether impairments on these abstract tasks extend to everyday spatial and navigational behaviour. Patients with hydrocephalus, but without spina bifida, were compared to a control group on tests of searching behaviour, landmark memory, route learning, and path integration. Participants with hydrocephalus displayed reduced sensitivity to spatial cueing, less accurate route-learning, and significantly less accurate spatial updating. These data represent an important empirical demonstration of spatial navigational impairments due to hydrocephalus outside of the context of spina bifida. We discuss some of the cognitive, neural, and individual differences factors that might contribute to this particular pattern of impairments.