Associations of lncRNA H19 Polymorphisms at MicroRNA Binding Sites with Glioma Susceptibility and Prognosis

• Published in: Molecular therapy. Nucleic acids Vol. 20; pp. 86 - 96
• Main Authors: Deng, Yujiao, Zhou, Linghui, Yao, Jia, Liu, Yu, Zheng, Yi, Yang, Si, Wu, Ying, Li, Na, Xu, Peng, Lyu, Lijuan, Zhang, Dai, Lyu, Jun, Dai, Zhijun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.06.2020; American Society of Gene & Cell Therapy; Elsevier
• Subjects: glioma; H19; prognosis; single nucleotide polymorphisms; susceptibility; H19; glioma; susceptibility; single nucleotide polymorphisms; prognosis
• ISSN: 2162-2531; 2162-2531
• DOI: 10.1016/j.omtn.2020.02.003

Glioma is the most common tumor of the central nervous system; variation in susceptibility and prognosis worldwide suggests that there are molecular and genetic differences among individuals. The H19 gene plays a dual role in carcinogenesis. In this study, associations between H19 polymorphisms and susceptibility as well as prognosis in glioma were evaluated. In total, 605 patients with glioma and 1,300 cancer-free subjects were enrolled in the study. Individuals with the rs3741219 A>G allele were less likely to develop glioma (relative risk [RR] = 0.54, 95% confidence interval [95% CI] = 0.45–0.63, p < 0.001), whereas rs217727 G>A and rs2839698 G>A genotypes were not associated with glioma risk. The associations between H19 polymorphisms and prognosis were assessed, including overall survival and progression-free survival. Three focused H19 polymorphisms did not show a significant effect on survival. Further analysis based on false-positive report probability validated these significant results. In the haplotype analysis, individuals with the Grs217727Ars2839698Grs3741219 haplotype were less likely to develop glioma (odds ratio [OR] = 0.33, 95% CI = 0.23–0.46, p = 0.02). Overall, carriers of the rs3741219 AG or GG genotype of H19 have a decreased susceptibility to glioma, but polymorphisms in this gene are not related to prognosis.