Reduction of abdominal fat accumulation in rats by 8-week ingestion of a newly developed sweetener made from high fructose corn syrup

• Published in: Food chemistry Vol. 138; no. 2-3; pp. 781 - 785
• Main Authors: Iida, Tetsuo, Yamada, Takako, Hayashi, Noriko, Okuma, Kazuhiro, Izumori, Ken, Ishii, Reika, Matsuo, Tatsuhiro
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.06.2013; Elsevier
• Subjects: Abdominal fat; Abdominal Fat - metabolism; Animals; Biological and medical sciences; blood glucose; Body Weight; diet; Down-Regulation; Food additives; Food industries; Fructose - metabolism; Fundamental and applied biological sciences. Psychology; General aspects; Glucose - metabolism; High fructose corn syrup; Humans; ingestion; insulin; Insulin - metabolism; isomerization; Male; Obesity; Obesity - diet therapy; Obesity - metabolism; Rare sugar; Rats; Rats, Wistar; starch; sugars; sweeteners; Sweetening Agents - analysis; Sweetening Agents - metabolism; Zea mays - chemistry; Obesity; GI; Abdominal fat; AMP; Body weight; High fructose corn syrup; Rare sugar; HFCS; TC; Ins; Glu; RSS; TG; VLDL; L-TG; L-Gly; USDA; ATP; Rat; Rodentia; Food additive; Ingestion; Corn syrup; Vertebrata; Reduction; Mammalia; Animal; Fructose syrup; Fat; Sweetener; Sugar
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2012.11.017

► We produced a rare sugar syrup (RSS) containing rare sugars such as d-psicose. ► We examined the anti-obesity effects of RSS as compared with starch and HFCS diets. ► Long-term intake of RSS suppressed abdominal fat accumulation. ► Intake of RSS improved carbohydrate metabolism. Many studies have shown that ingestion of high-fructose corn syrup (HFCS) may cause an increase in body weight and abdominal fat. We recently developed a new sweetener containing rare sugars (rare sugar syrup; RSS) by slight isomerization of HFCS. Here, the functional effects of RSS on body weight and abdominal fat, and biochemical parameters in Wistar rats were examined. Rats (n=30) were randomly divided into three groups and maintained for 8-weeks on starch, starch+HFCS (50:50), and starch+RSS (50:50) diets. Rats in the Starch and HFCS groups gained significantly more body weight and abdominal fat than the RSS group. Fasting serum insulin in the RSS group was significantly lower than in the Starch and HFCS groups, although serum glucose in the HFCS and RSS groups was significantly lower than that in the Starch group. Thus, the substitution of HFCS with RSS prevents obesity induced by the consumption of HFCS.