Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis

• Published in: International journal of surgery (London, England) Vol. 26; pp. 32 - 37
• Main Authors: Zu, Guo, Ji, Anlong, Zhou, Tingting, Che, Ningwei
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2016
• Subjects: Biomarkers, Tumor - metabolism; Clinicopathological characteristics; Colorectal cancer; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Humans; Lymphatic Metastasis; Neoplasm Invasiveness; Prognosis; SIRT1; Sirtuin 1 - metabolism; Surgery; Survival Analysis; Clinicopathological characteristics; Prognosis; SIRT1; Colorectal cancer
• ISSN: 1743-9191; 1743-9159
• DOI: 10.1016/j.ijsu.2016.01.002

Abstract Purpose The relationship between SIRT1 and clinicopathological parameters of colorectal cancer (CRC) is controversial. To evaluate the clinicopathological and prognostic value of silent mating type information regulation 2 homolog-1 (SIRT1) expressions in patients with CRC, a meta-analysis was performed. Methods We conducted a meta-analysis to investigate the impact of SIRT1 on clinicopathological parameters and prognosis in CRC patients. Studies assessing the relationship between these parameters and SIRT1 expression in CRC were identified up to September, 2015. Results Seven studies met the inclusion criteria. Our results showed that SIRT1 expression was correlated with depth of invasion (OR = 0.922, 95% CI: 0.646–1.316, P  = 0.005), lymph node metastasis (OR = 1.001, 95% CI: 0.781–1.283, P  = 0.000) and TNM stage (OR = 1.103, 95% CI: 0.892–1.365, P  = 0.008). Furthermore, we found that SIRT1 expression predicted a poor overall survival (OS) in CRC patients (OR = 1.220, 95% CI: 0.955–1.558, P  = 0.037, fixed-effect). Conclusions The overall data of the present meta-analysis showed that SIRT1 expression was not correlated with clinicopathological features except for depth of invasion, lymph node metastasis and TNM stage. Simultaneously, SIRT1 overexpression predicted a poor OS in CRC patients, and SIRT1 is a candidate negative prognostic biomarker for CRC patients.