Mammalian sperm chromatin structure and assessment of DNA fragmentation

This review article illustrates the biology of mammalian sperm chromatin structure. The possible causes of DNA (deoxyribonucleic acid) fragmentation are discussed. Also available molecular techniques for assessment of mammalian sperm DNA damage are described.

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Bibliographic Details
Published inJournal of assisted reproduction and genetics Vol. 24; no. 12; pp. 561 - 569
Main Author Andrabi, S M H
Format Journal Article
LanguageEnglish
Published Netherlands Springer Nature B.V 01.12.2007
Springer US
Subjects
Amino acids
Animals
Apoptosis - genetics
Apoptosis - physiology
Chromatin - chemistry
DNA Damage
DNA Fragmentation
DNA methylation
DNA Packaging - physiology
Genes
Genetic Techniques
Genomes
Histones - metabolism
Histones - physiology
Humans
Male
Nuclear Proteins - metabolism
Nuclear Proteins - physiology
Oxidative Stress - genetics
Oxidative Stress - physiology
Phosphorylation
Protamines - metabolism
Proteins
Sperm
Spermatogenesis
Spermatozoa - metabolism
Spermatozoa - ultrastructure
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Summary:This review article illustrates the biology of mammalian sperm chromatin structure. The possible causes of DNA (deoxyribonucleic acid) fragmentation are discussed. Also available molecular techniques for assessment of mammalian sperm DNA damage are described.
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ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-007-9177-y