Effect of polymer type on characteristics of buccal tablets using factorial design

• Published in: Saudi pharmaceutical journal Vol. 26; no. 1; pp. 53 - 63
• Main Authors: Esim, O., Savaser, A., Ozkan, C.K., Bayrak, Z., Tas, C., Ozkan, Y.
• Format: Journal Article
• Language: English
• Published: Saudi Arabia Elsevier B.V 01.01.2018; Elsevier
• Subjects: Buccal tablet; Carbopol; Chitosan; Effect of polymer; Hydrophilic matrix; Carbopol; Hydrophilic matrix; Effect of polymer; Buccal tablet; Chitosan
• ISSN: 1319-0164; 2213-7475
• DOI: 10.1016/j.jsps.2017.10.013

A two factor three level factorial design was used to investigate the effects of carbopol and cationic hydrophilic polymers which have a common use in buccal drug formulations. Statistical models with interaction terms were derived to evaluate influence of carbopol (X1) and chitosan (X2) on tablet disintegration (Y1) and dissolution (Y2), mechanical properties (Y3), swelling (Y4). Tablet disintegration studies were carried out using two different pH environments within buccal region pH limits and also two different commonly used dissolution methods for buccal tablets were also investigated to compare the effect of polymer type on dissolution. Polymer type and ratio affect the characteristics of the buccal tablets due to their different physicochemical behavior at buccal pH. Also significant variances between dissolution profiles for buccal tablets, using either USP Paddle or flow through cell methods were found. These results indicate that both polymer type and ratio as well as combination of them effects the drug behavior in different ways.