Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this v...

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Published iniScience Vol. 25; no. 9; p. 104985
Main Authors Simola, Jaana, Siebenhühner, Felix, Myrov, Vladislav, Kantojärvi, Katri, Paunio, Tiina, Palva, J. Matias, Brattico, Elvira, Palva, Satu
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 16.09.2022
Elsevier
Subjects
Biological sciences
Cognitive neuroscience
Neuroscience
Cognitive neuroscience
Neuroscience
Biological sciences
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Summary:Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework. [Display omitted] •Human local oscillation dynamics is influenced by polymorphisms in COMT and BNDF•COMT and BDNF influence oscillation amplitudes and long-range temporal correlations•BDNF polymorphism affected the strength of large-scale synchronization•Framework of brain criticality links COMT and BDNF with local E/I-balance Biological sciences; Neuroscience; Cognitive neuroscience
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These authors contributed equally
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ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2022.104985