Necrotizing enterocolitis following diazoxide therapy for persistent neonatal hypoglycemia

Recalcitrant neonatal hypoglycemia poses a treatment challenge for clinicians. When a patient's hypoglycemia does not respond to dextrose infusion, several medication options are available, including diazoxide(1,2). Several side effects of diazoxide are described in the literature, including fl...

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Bibliographic Details
Published inJournal of pediatric surgery case reports Vol. 52; p. 101356
Main Authors Theodorou, Christina M., Hirose, Shinjiro
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.01.2020
Elsevier
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Summary:Recalcitrant neonatal hypoglycemia poses a treatment challenge for clinicians. When a patient's hypoglycemia does not respond to dextrose infusion, several medication options are available, including diazoxide(1,2). Several side effects of diazoxide are described in the literature, including fluid retention with the risk of development of congestive heart failure(3,4). We describe a case of necrotizing enterocolitis in a patient with Beckwith-Wiedemann Syndrome with persistent neonatal hypoglycemia who was treated with increasing doses of diazoxide. •Diazoxide is a commonly used medication to treat hypoglycemia.•Known side effects include fluid retention and congestive heart failure.•Necrotizing enterocolitis may occur with high-dose diazoxide treatment in neonates.
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Authorship
All authors attest that they meet current ICMJE criteria for Authorship. CT, SH.
ISSN:2213-5766
2213-5766
DOI:10.1016/j.epsc.2019.101356