Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19

• Published in: Acta pharmaceutica Sinica. B Vol. 13; no. 9; pp. 3638 - 3658
• Main Authors: Liu, Zhicheng, Han, Zhuolei, Jin, Xin, An, Jusung, Kim, Jaewon, Chen, Wenting, Kim, Jong Seung, Zheng, Ji, Deng, Jun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2023; Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V; Elsevier
• Subjects: Altered homeostasis; Coronavirus disease 19; Microenvironment; Microenvironmental disorder; Nanomaterial technologies; Nanotechnology; Review; Severe acute respiratory syndrome coronavirus 2; Therapeutic approaches; Coronavirus disease 19; Severe acute respiratory syndrome coronavirus 2; Microenvironmental disorder; Therapeutic approaches; Nanomaterial technologies; Altered homeostasis; Microenvironment; Nanotechnology
• ISSN: 2211-3835; 2211-3843
• DOI: 10.1016/j.apsb.2023.02.010

COVID-19, caused by SARS-CoV-2, has resulted in serious economic and health burdens. Current treatments remain inadequate to extinguish the epidemic, and efficient therapeutic approaches for COVID-19 are urgently being sought. Interestingly, accumulating evidence suggests that microenvironmental disorder plays an important role in the progression of COVID-19 in patients. In addition, recent advances in nanomaterial technologies provide promising opportunities for alleviating the altered homeostasis induced by a viral infection, providing new insight into COVID-19 treatment. Most literature reviews focus only on certain aspects of microenvironment alterations and fail to provide a comprehensive overview of the changes in homeostasis in COVID-19 patients. To fill this gap, this review systematically discusses alterations of homeostasis in COVID-19 patients and potential mechanisms. Next, advances in nanotechnology-based strategies for promoting homeostasis restoration are summarized. Finally, we discuss the challenges and prospects of using nanomaterials for COVID-19 management. This review provides a new strategy and insights into treating COVID-19 and other diseases associated with microenvironment disorders. Nanomaterials can server as potential strategies to ameliorate COVID-19 via regulating the disordered microenvironment of patients. [Display omitted]