Reviving the promise of transcription factor Nrf2-based therapeutics for kidney diseases

The transcription factor Nrf2 plays an important role in many kidney diseases from acute kidney injury to chronic kidney disease, and there have been preliminary Nrf2-based therapeutic trials in humans. Shelton et al. presents an integrated transcriptomic and proteomic analysis of mouse kidney to re...

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Published inKidney international Vol. 88; no. 6; pp. 1217 - 1218
Main Authors Noel, Sanjeev, Hamad, Abdel R.A., Rabb, Hamid
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.2015
Elsevier Limited
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Summary:The transcription factor Nrf2 plays an important role in many kidney diseases from acute kidney injury to chronic kidney disease, and there have been preliminary Nrf2-based therapeutic trials in humans. Shelton et al. presents an integrated transcriptomic and proteomic analysis of mouse kidney to reveal Nrf2 targets with potentially important roles in kidney homeostasis and pathophysiology. These results can further our understanding of Nrf2-based mechanisms and help in the development of therapeutics for a wide range of kidney diseases.
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ISSN:0085-2538
1523-1755
DOI:10.1038/ki.2015.328