Spindle cell oncocytoma of the sella turcica with anaplastic features and rapid progression in short-term follow-up: a case report with proposal of distinctive radiologic features

• Published in: Journal of pathology and translational medicine Vol. 55; no. 3; pp. 225 - 229
• Main Authors: Kim, Dong Ja, Lee, SangHan, Kim, Mee-seon, Hwang, Jeong-Hyun, Hahm, Myong Hun
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society of Pathologists, Korean Society for Cytopathology 01.05.2021; The Korean Society of Pathologists and the Korean Society for Cytopathology; Korean Society of Pathologists & the Korean Society for Cytopathology; 대한병리학회
• Subjects: Case reports; Case Study; Cytoplasm; Hormones; Magnetic resonance imaging; neoplasms; oncocytoma; Patients; Pituitary gland; progression; Radiation therapy; radiology; sella turcica; Surgery; Thyroid gland; Transcription factors; Tumors; 병리학; Progression; Oncocytoma; Radiology; Neoplasms; Sella turcica
• ISSN: 2383-7837; 2383-7845
• DOI: 10.4132/jptm.2021.01.27

We present a rare case of spindle cell oncocytoma (SCO) of the sella turcica with malignant histologic features and rapid progression. A 42-year-old woman experienced bilateral blurred vision and was preoperatively misdiagnosed as having a pituitary macroadenoma on magnetic resonance imaging. After surgery, SCO was diagnosed by the histopathologic features of interlacing fascicles of spindle tumor cells with finely granular, eosinophilic cytoplasm. Focal anaplastic changes and necrosis were present. Immunohistochemically, the tumor cells were positive for vimentin, epithelial membrane antigen, S-100, galectin-3, and thyroid transcription factor 1. Four months later, the tumor had progressed, and second surgery with adjuvant radiotherapy was performed; the patients remains under observation. In this report, we proposed distinctive radiologic features for differential diagnosis between SCO and other pituitary tumors.