Capecitabine-induced bilateral ectropion: A rare ocular manifestation requiring surgical intervention

It has been established that many chemotherapeutic agents are associated with a variety of ocular side effects. As an antineoplastic agent, 5-fluorouracil (5-FU) is the chemotherapeutic agent that is frequently linked with cicatricial ectropion. Capecitabine is a prodrug of 5-FU and has a more favor...

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Published inJournal of cutaneous and aesthetic surgery Vol. 11; no. 4; pp. 241 - 244
Main Authors Tatar, Sedat, Yalçın, Can, Sezgin, Billur, Taş, Ayşe, Müftüoğlu, Orkun, Özmen, Selahattin
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.10.2018
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
5-fluorouracil
Abdomen
Biopsy
Capecitabine
Care and treatment
Case Report
Case studies
Chemotherapy
Complications and side effects
Constipation
Dermatology
Diarrhea
ectropion
Enzymes
Eyelid diseases
Fluorouracil
Pain
Patients
Plastic surgery
Postoperative period
Skin & tissue grafts
skin grafting
Surgery
5-fluorouracil
ectropion
Capecitabine
skin grafting
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Summary:It has been established that many chemotherapeutic agents are associated with a variety of ocular side effects. As an antineoplastic agent, 5-fluorouracil (5-FU) is the chemotherapeutic agent that is frequently linked with cicatricial ectropion. Capecitabine is a prodrug of 5-FU and has a more favorable side effect profile than 5-FU. Frequent side effects of capecitabine include gastrointestinal events and hand-foot-mouth syndrome; cicatricial ectropion is rather uncommon. Enzyme deficiencies affecting the capecitabine metabolism have been reported to be associated with exaggerated generalized systemic and cutaneous side effects; however, there are no cases in the literature reporting capecitabine-induced isolated bilateral-progressive ectropion. Although cessation of the agent is frequently sufficient for the treatment of ectropion, close follow-up is indicated in such patients as permanent damage may occur if the problem is left untreated. We report a case of capecitabine-induced bilateral cicatricial ectropion refractory to treatment cessation, ultimately requiring surgical treatment.
ISSN:0974-2077
0974-5157
DOI:10.4103/JCAS.JCAS_5_18