Pathogenesis of haemophilic arthropathy

• Published in: Haemophilia : the official journal of the World Federation of Hemophilia Vol. 12; no. s3; pp. 117 - 121
• Main Authors: ROOSENDAAL, G., LAFEBER, F. P.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2006
• Subjects: arthropathy; blood; cartilage; Cartilage Diseases - etiology; Cartilage, Articular; haemophilic; Hemarthrosis - complications; Hemophilia A - complications; Humans; Joint Diseases - etiology; Male; Synovitis - etiology; synovium

The pathogenetic mechanism of haemophilic arthropathy is multifactorial and includes degenerative cartilage‐mediated and inflammatory synovium‐mediated components. Intra‐articular blood first has a direct effect on cartilage, as a result of the iron‐catalysed formation of destructive oxygen metaboli...