Pathogenesis of haemophilic arthropathy

The pathogenetic mechanism of haemophilic arthropathy is multifactorial and includes degenerative cartilage‐mediated and inflammatory synovium‐mediated components. Intra‐articular blood first has a direct effect on cartilage, as a result of the iron‐catalysed formation of destructive oxygen metaboli...

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Bibliographic Details
Published inHaemophilia : the official journal of the World Federation of Hemophilia Vol. 12; no. s3; pp. 117 - 121
Main Authors ROOSENDAAL, G., LAFEBER, F. P.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.07.2006
Subjects
arthropathy
blood
cartilage
Cartilage Diseases - etiology
Cartilage, Articular
haemophilic
Hemarthrosis - complications
Hemophilia A - complications
Humans
Joint Diseases - etiology
Male
Synovitis - etiology
synovium
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Summary:The pathogenetic mechanism of haemophilic arthropathy is multifactorial and includes degenerative cartilage‐mediated and inflammatory synovium‐mediated components. Intra‐articular blood first has a direct effect on cartilage, as a result of the iron‐catalysed formation of destructive oxygen metabolites (resulting in chondrocyte apoptosis), and subsequently affects the synovium, in addition to haemosiderin‐induced synovial triggering. Both processes occur in parallel, and while they influence each other they probably do not depend on each other. This concept resembles degenerative joint damage as found in osteoarthritis as well as inflammatory processes in rheumatoid arthritis. These processes finally result in a fibrotic and destroyed joint.
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ObjectType-Review-1
ISSN:1351-8216
1365-2516
DOI:10.1111/j.1365-2516.2006.01268.x