Novel PCA-VIP scheme for ranking MRI protocols and identifying computer-extracted MRI measurements associated with central gland and peripheral zone prostate tumors
Purpose To identify computer‐extracted features for central gland and peripheral zone prostate cancer localization on multiparametric magnetic resonance imaging (MRI). Materials and Methods Preoperative T2‐weighted (T2w), diffusion‐weighted imaging (DWI), and dynamic contrast‐enhanced (DCE) MRI were...
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Published in | Journal of magnetic resonance imaging Vol. 41; no. 5; pp. 1383 - 1393 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.05.2015
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose
To identify computer‐extracted features for central gland and peripheral zone prostate cancer localization on multiparametric magnetic resonance imaging (MRI).
Materials and Methods
Preoperative T2‐weighted (T2w), diffusion‐weighted imaging (DWI), and dynamic contrast‐enhanced (DCE) MRI were acquired from 23 men with confirmed prostate cancer. Following radical prostatectomy, the cancer extent was delineated by a pathologist on ex vivo histology and mapped to MRI by nonlinear registration of histology and corresponding MRI slices. In all, 244 computer‐extracted features were extracted from MRI, and principal component analysis (PCA) was employed to reduce the data dimensionality so that a generalizable classifier could be constructed. A novel variable importance on projection (VIP) measure for PCA (PCA‐VIP) was leveraged to identify computer‐extracted MRI features that discriminate between cancer and normal prostate, and these features were used to construct classifiers for cancer localization.
Results
Classifiers using features selected by PCA‐VIP yielded an area under the curve (AUC) of 0.79 and 0.85 for peripheral zone and central gland tumors, respectively. For tumor localization in the central gland, T2w, DCE, and DWI MRI features contributed 71.6%, 18.1%, and 10.2%, respectively; for peripheral zone tumors T2w, DCE, and DWI MRI contributed 29.6%, 21.7%, and 48.7%, respectively.
Conclusion
PCA‐VIP identified relatively stable subsets of MRI features that performed well in localizing prostate cancer on MRI. J. Magn. Reson. Imaging 2015;41:1383–1393. © 2014 Wiley Periodicals, Inc. |
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Bibliography: | istex:149E52D4802074483440C6A85EB9D82A99EB56DB National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health - No. R43EB015199-01 ark:/67375/WNG-19SKSZMZ-B ArticleID:JMRI24676 National Cancer Institute of the National Institutes of Health - No. R01CA136535-01, R01CA140772-01, and R21CA167811-01 National Science Foundation - No. IIP-1248316 University City Science Center and Rutgers University National Science Foundation Graduate Research Fellowship Supported by the National Cancer Institute of the National Institutes of Health under award numbers R01CA136535‐01, R01CA140772‐01, and R21CA167811‐01; the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under award number R43EB015199‐01; the National Science Foundation under award number IIP‐1248316; the QED award from the University City Science Center and Rutgers University; and the National Science Foundation Graduate Research Fellowship. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 1053-1807 1522-2586 1522-2586 |
DOI: | 10.1002/jmri.24676 |