Anti-diabetic Activity Present in the Fruit Body of Grifola frondosa (Maitake). I

• Published in: Biological & pharmaceutical bulletin Vol. 17; no. 8; pp. 1106 - 1110
• Main Authors: KUBO, Keiko, AOKI, Hisao, NANBA, Hiroaki
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1994; Maruzen; Japan Science and Technology Agency
• Subjects: Animals; anti-diabetic activity; Biological and medical sciences; blood glucose; Blood Glucose - metabolism; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; Female; General pharmacology; Grifola frondosa (maitake); Hypoglycemic Agents - pharmacology; Insulin - blood; KK-Ay mouse; Medical sciences; Mice; Mice, Inbred Strains; NIDDM; Peptidoglycan - metabolism; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Polyporaceae - chemistry; Triglycerides - blood; Endocrinopathy; Fruit; Pharmacognosy; Diabetes mellitus; Rodentia; Oral administration; Basidiomycetes; Biological activity; Fungi; Vertebrata; Chemotherapy; Hypoglycemic agent; Experimental disease; Mammalia; Treatment; Mouse; Animal; Plant origin; Thallophyta
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.17.1106

The fruit body of Grifola frondosa (maitake), Basidiomycetes was confirmed to contain substances with anti-diabetic activity. When 1g/d of powdered fruit body of maitake was given orally to a genetically diabetic mouse (KK-Ay), blood glucose reduction was observed, in contrast to the control group in which the blood glucose increased with ageing. Moreover, levels of insulin and triglyceride in plasma demonstrated a change similar to blood glucose with feeding of maitake. Ether-ethanol-soluble (ES) and hot water-soluble (WS) fractions were prepared from the fruit body and their hypoglycemic activity was examined. Blood glucose-lowering activity was found when ES-fraction or WS-50% ethanol float (X) fraction was administered orally, but other WS-fractions were inactive. These results suggest that the anti-diabetic activity was present not only in the ES-fraction consisting of lipid but also in the X-fraction of peptidoglycan (sugar : protein=65 : 35).