Peptide Fragment Coupling Using a Continuous-Flow Photochemical Rearrangement of Nitrones
Go with the flow: A general approach for amide bond formation by way of a continuous‐flow photochemical rearrangement of nitrones was described (see scheme). Simple aryl‐alkyl amide bonds as well as complex peptide bonds were constructed efficiently with a residence time less than 20 minutes. A tetr...
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Published in | Angewandte Chemie (International ed.) Vol. 52; no. 15; pp. 4251 - 4255 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
08.04.2013
WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc |
Edition | International ed. in English |
Subjects | |
Online Access | Get full text |
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Summary: | Go with the flow: A general approach for amide bond formation by way of a continuous‐flow photochemical rearrangement of nitrones was described (see scheme). Simple aryl‐alkyl amide bonds as well as complex peptide bonds were constructed efficiently with a residence time less than 20 minutes. A tetrapeptide was synthesized in this way and the method could be applied to peptide fragment coupling. |
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Bibliography: | istex:5B0A33DEB19C883A162698ACF26E74AE85792B44 Novartis-MIT Center for Continuous Manufacturing ark:/67375/WNG-PJKWFCGD-C ArticleID:ANIE201300504 We are grateful to the Novartis-MIT Center for Continuous Manufacturing for financial support. We thank several colleagues at MIT (Dr. Andrew S. Kleinke, Dr. James J. Mousseau, Dr. Ping Zhang, and Kurt Armbrust) and at Novartis (Dr. Guido Koch, Dr. Berthold Schenkel, Dr. Gerhard Penn, Dr. Benjamin Martin, and Dr. Jörg Sedelmeier) for insightful discussions. We also thank Eric Standley (MIT) and Li Li (MIT) for obtaining mass spectrometric data. We are grateful to the Novartis‐MIT Center for Continuous Manufacturing for financial support. We thank several colleagues at MIT (Dr. Andrew S. Kleinke, Dr. James J. Mousseau, Dr. Ping Zhang, and Kurt Armbrust) and at Novartis (Dr. Guido Koch, Dr. Berthold Schenkel, Dr. Gerhard Penn, Dr. Benjamin Martin, and Dr. Jörg Sedelmeier) for insightful discussions. We also thank Eric Standley (MIT) and Li Li (MIT) for obtaining mass spectrometric data. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.201300504 |