Metabolism of 9, 3"-Diacetylmidecamycin. II. The Structures of Several Metabolites of 9, 3"-Diacetylmidecamycin

The structures of several metabolites of 9, 3"-diacetylmidecamycin were studied by means of nuclear magnetic resonance (NMR) and mass spectroscopy. It was shown that these metabolites are a pair of 14-hydroxylated compounds which differ in the stereochemistry at carbon-14 of the macrocyclic lac...

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Published inChemical & pharmaceutical bulletin Vol. 29; no. 9; pp. 2413 - 2419
Main Authors SHOMURA, TOMOKO, SOMEYA, SAWAKO, MURATA, SHINJIRO, UMEMURA, KOSHIRO, NISHIO, MOTOHIRO
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 1981
Japan Science and Technology Agency
Subjects
Biotransformation
Chemical Phenomena
Chemistry
Humans
Leucomycins - metabolism
Miocamycin
γ-gauche effect
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Summary:The structures of several metabolites of 9, 3"-diacetylmidecamycin were studied by means of nuclear magnetic resonance (NMR) and mass spectroscopy. It was shown that these metabolites are a pair of 14-hydroxylated compounds which differ in the stereochemistry at carbon-14 of the macrocyclic lactone ring, and the corresponding 9-de-acetylated products.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.29.2413