Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region

The craniofacial region contains many specified tissues including bone, cartilage, muscle, blood vessels and neurons. Defect or dysfunction of the craniofacial tissue after post‐cancer ablative surgery, trauma, congenital malformations and progressive deforming skeletal diseases has a huge influence...

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Bibliographic Details
Published inOral diseases Vol. 12; no. 6; pp. 514 - 522
Main Authors Miura, M, Miura, Y, Sonoyama, W, Yamaza, T, Gronthos, S, Shi, S
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.11.2006
Subjects
Animals
Bone Marrow Cells - physiology
Bone Marrow Transplantation
Dentistry
differentiation
Face - surgery
Humans
mesenchymal stem cell (MSC)
Mesenchymal Stem Cell Transplantation
Mesenchymal Stromal Cells - physiology
Multipotent Stem Cells - physiology
Regeneration - physiology
Skull - surgery
Tissue Engineering
tissue regeneration
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Summary:The craniofacial region contains many specified tissues including bone, cartilage, muscle, blood vessels and neurons. Defect or dysfunction of the craniofacial tissue after post‐cancer ablative surgery, trauma, congenital malformations and progressive deforming skeletal diseases has a huge influence on the patient's life. Therefore, functional reconstruction of damaged tissues is highly expected. Bone marrow‐derived mesenchymal stem cells (BMMSCs) are one of the most well characterized postnatal stem cell populations, and considered to be utilized for cell‐based clinical therapies. Here, the current understanding and the potential applications in craniofacial tissue regeneration of BMMSCs are reviewed, and the current limitations and drawbacks are also discussed.
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ArticleID:ODI1300
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ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2006.01300.x