Regenerative Potential of a Suspension and Spheroids of Multipotent Mesenchymal Stromal Cells from Human Umbilical Cord on the Model of Myocardial Infarction in Rats

• Published in: Bulletin of experimental biology and medicine Vol. 169; no. 4; pp. 549 - 557
• Main Authors: Krasina, M. E., Kosheleva, N. V., Lipina, T. V., Karganov, M. Yu, Medvedeva, Yu. S., Lebedeva, M. A., Zurina, I. M., Saburina, I. N.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2020; Springer
• Subjects: Biomedical and Life Sciences; Biomedicine; Cell Biology; Heart; Heart attack; Internal Medicine; Laboratory Medicine; Pathology; Stem cells; Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine); isoproterenol; spheroids; multipotent mesenchymal stromal cells; myocardial infarction
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-020-04928-0

Regenerative potential of multipotent mesenchymal stromal cells from the human umbilical cord (MMSC-UC) in the suspension and spheroid form was revealed during the progression of experimental small focal myocardial infarction in rats. In isoproterenol-induced myocardial infarction, foci of necrosis and inflammatory infiltrate and at later terms fibrosis foci were found mainly in the left ventricle of rat heart. In rats receiving MMSC-UC, destructive changes in the myocardium, fibrous scars, and inflammatory process were less pronounced. MMSC-UC also contributed to normalization of the morphofunctional parameters of the heart. Spheroids exhibited higher efficiency in comparison with cell suspension.