Is Osteopontin a Good Marker for Bone Metastasis in Canine Mammary Gland Tumor and Prostate Cancer?

Osteopontin (OPN) is a protein synthesized by a large number of cells, and its overexpression has been associated with the development and prognosis of cancer. OPN overexpression has been claimed to be a marker for the development of bone metastasis in human cancers, but no prior research has invest...

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Published inAnimals (Basel) Vol. 13; no. 20; p. 3211
Main Authors Grisoni Sanchez, Caroline, Figueiredo, Marxa Leão, de Sartori Camargo, Laíza, Benevenuto, Luiz Guilherme Dercore, Lacerda, Zara Alves, Fonseca-Alves, Carlos Eduardo
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2023
MDPI
Subjects
Angiogenesis
Animals
Bones
Breast cancer
Cancer
Cancer therapies
canine
carcinoma
Development and progression
Dogs
Females
Fibroblasts
Growth factors
Immune system
mammary gland
Medical prognosis
Metastasis
Oncology, Experimental
osteopontin
Pathogenesis
Prognosis
prostate
Prostate cancer
Proteins
Survival analysis
Tumors
Veterinary medicine
United States > US
Germany
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Summary:Osteopontin (OPN) is a protein synthesized by a large number of cells, and its overexpression has been associated with the development and prognosis of cancer. OPN overexpression has been claimed to be a marker for the development of bone metastasis in human cancers, but no prior research has investigated the association between OPN expression and the metastasis of canine mammary gland tumors (MGTs) and prostate cancer (PC). Therefore, we investigated OPN expression in MGTs and PC samples from 50 canine patients with or without metastasis (bone vs. other sites). Higher OPN expression was detected in primary tumor samples from animals with bone metastasis than in those without bone involvement (p = 0.0321). In MGT samples, a significantly lower survival rate was observed in patients with higher OPN expression (p = 0.0171). In animals with PC, there was a strong trend toward lower survival in animals with positive OPN expression; however, this trend was not statistically significant (p = 0.0779). From these findings, it can be concluded that OPN may be a promising target for future MGTs and PC studies because of its role in enhancing cell invasion and metastasis.
Bibliography:ObjectType-Article-1
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ISSN:2076-2615
2076-2615
DOI:10.3390/ani13203211