Automated individual cortical parcellation via consensus graph representation learning

• Published in: NeuroImage (Orlando, Fla.) Vol. 293; p. 120616
• Main Authors: Wen, Xuyun, Yang, Mengting, Qi, Shile, Wu, Xia, Zhang, Daoqiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2024; Elsevier Limited; Elsevier
• Subjects: Automation; Brain architecture; Brain mapping; Cortical parcellation; Embedding; Functional magnetic resonance imaging; Graph representations; Learning; Low-rank tensor learning; Magnetic resonance imaging; Neural networks; Neuroimaging; Spectral embedding; Functional magnetic resonance imaging; Spectral embedding; Cortical parcellation; Low-rank tensor learning
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2024.120616

Cortical parcellation plays a pivotal role in elucidating the brain organization. Despite the growing efforts to develop parcellation algorithms using functional magnetic resonance imaging, achieving a balance between intra-individual specificity and inter-individual consistency proves challenging, making the generation of high-quality, subject-consistent cortical parcellations particularly elusive. To solve this problem, our paper proposes a fully automated individual cortical parcellation method based on consensus graph representation learning. The method integrates spectral embedding with low-rank tensor learning into a unified optimization model, which uses group-common connectivity patterns captured by low-rank tensor learning to optimize subjects’ functional networks. This not only ensures consistency in brain representations across different subjects but also enhances the quality of each subject’s representation matrix by eliminating spurious connections. More importantly, it achieves an adaptive balance between intra-individual specificity and inter-individual consistency during this process. Experiments conducted on a test–retest dataset from the Human Connectome Project (HCP) demonstrate that our method outperforms existing methods in terms of reproducibility, functional homogeneity, and alignment with task activation. Extensive network-based comparisons on the HCP S900 dataset reveal that the functional network derived from our cortical parcellation method exhibits greater capabilities in gender identification and behavior prediction than other approaches. •Propose an efficient data-driven method for individual cortical parcellation of the human brain.•The generated cortical parcellation shows high functional homogeneity and consistency.•Individual cortical parcellation enhances the brain network’s gender and behavior prediction.