Acetic Acid-Catalyzed Diketopiperazine Synthesis

Optically pure diketopiperazines were obtained in good yields when dipeptide esters were refluxed in 2-butanol containing 0.1 M acetic acid for 3 hours. When prolyl-amino acid ester was used as the starting material, 1 to 2 M acetic acid was the most effective concentration.

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 29; no. 1; pp. 233 - 237
Main Authors MIHARA, YUICHI, ENDO, NOBUYOSHI, SUZUKI, KENJI, SASAKI, YUSUKE
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.01.1981
Japan Science and Technology Agency
Subjects
racemization test
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ISSN0009-2363
1347-5223
DOI10.1248/cpb.29.233

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Summary:Optically pure diketopiperazines were obtained in good yields when dipeptide esters were refluxed in 2-butanol containing 0.1 M acetic acid for 3 hours. When prolyl-amino acid ester was used as the starting material, 1 to 2 M acetic acid was the most effective concentration.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.29.233