PI-220, a new platelet aggregation inhibitor

PI-220 was found in a culture broth of Streptomyces sp. A8059, which had been isolated from a soil sample collected in Okinawa Prefecture, Japan. PI-220 inhibited aggregation of rabbit platelets with an IC 50 value of 1.0-2.1 × 10 -3 M.

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Bibliographic Details
Published inBioscience, biotechnology, and biochemistry Vol. 57; no. 5; pp. 766 - 769
Main Authors Kagamizono, T. (Taisho Pharmaceutical Co. Ltd., Omiya, Saitama (Japan)), Kawashima, A, Kishimura, Y, Yamagishi, M, Tsuchida, Y, Kondo, H, Hanada, K
Format Journal Article
LanguageEnglish
Published Tokyo Taylor & Francis 1993
Japan Society for Bioscience Biotechnology and Agrochemistry
Oxford University Press
Subjects
ANTICOAGULANT
ANTICOAGULANTES
ANTICOAGULANTS
Biological and medical sciences
BLOOD COAGULATION
Blood. Blood coagulation. Reticuloendothelial system
COAGULACION SANGUINEA
COAGULATION SANGUINE
Medical sciences
Pharmacology. Drug treatments
PLATELETS
STREPTOMYCES
THROMBOCYTE
TROMBOCITOS
Asia
Japan
Actinomycetales
Streptomycetaceae
Microbial origin
Molecular structure
Streptomyces
Bacteria
Actinomycetes
Fermentation
Biological activity
Antiplatelet agent
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Summary:PI-220 was found in a culture broth of Streptomyces sp. A8059, which had been isolated from a soil sample collected in Okinawa Prefecture, Japan. PI-220 inhibited aggregation of rabbit platelets with an IC 50 value of 1.0-2.1 × 10 -3 M.
Bibliography:9402334
F60
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.57.766