Impact of the Introduction of Government Use Licenses on the Drug Expenditure on Seven Medicines in Thailand

• Published in: Value in health Vol. 15; no. 1; pp. S95 - S99
• Main Authors: Mohara, Adun, MSc, Yamabhai, Inthira, MBA, Chaisiri, Kakanang, BSPs, Tantivess, Sripen, PhD, Teerawattananon, Yot, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2012
• Subjects: Budgets; Cost; Drugs; Drugs, Generic - economics; Fees, Pharmaceutical - statistics & numerical data; Generic prescribing; health expenditures; Humans; Internal Medicine; Licenses; Licensing; licensure; Licensure - economics; Markov Chains; Medical service; Models, Economic; Patents as Topic - statistics & numerical data; Patients; Prescription Drugs - economics; public policy; Savings; Sensitivity analysis; social change; Thailand; Thailand; licensure; health expenditures; social change; public policy
• ISSN: 1098-3015; 1524-4733
• DOI: 10.1016/j.jval.2011.11.016

Abstract Objectives To assess the budget impact of the government use licenses policy, a form of compulsory licensing used by the government, on seven patented drugs, namely, efavirenz, lopinavir/ritonavir combination, clopidogrel, letrozole, docetaxel, erlotinib, and imatinib, in Thailand between 2006 and 2008. Methods By using government's perspective, budget impact was estimated within a 5-year period after the introduction of the policy. The number of patients who need treatment with each drug and the costs of treatments by both original and generic versions were obtained from Thai government agencies. Probabilistic sensitivity analysis was used to determine the impact of uncertainty surrounding parameters such as the numbers of patients and the health-care costs. Results The study indicated that the use of generic drugs under the policy could save the government budget approximately $370 million over 5 years. It was also found that each drug had a different effect on budget saving depending on the number of patients treated, the difference in drug costs between original and generic drugs, and the lag time from the introduction of the policy to the availability of the generic drugs on the market. Conclusion The study showed that the introduction of the government use licenses policy in Thailand would provide significant benefits for the study timeframe; however, there are several issues that should be taken into account when the government use licenses policy is adopted.