Maternal serum leptin concentration in gestational diabetes

Abstract Objective The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (IGT). Materials and Methods This case-control study, at 28 weeks of gestati...

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Published inTaiwanese journal of obstetrics & gynecology Vol. 50; no. 2; pp. 149 - 153
Main Authors Soheilykhah, Sedigheh, Mojibian, Mahdieh, Rahimi-Saghand, Soodabeh, Rashidi, Maryam, Hadinedoushan, Hossein
Format Journal Article
LanguageEnglish
Published China (Republic : 1949- ) Elsevier B.V 01.06.2011
Elsevier
Subjects
Adult
Body Mass Index
Case-Control Studies
Diabetes, Gestational - blood
Female
Gestational diabetes mellitus
Glucose Tolerance Test
Humans
Impaired glucose tolerance test
Insulin - blood
Insulin Resistance
Internal Medicine
Leptin
Leptin - blood
Obstetrics and Gynecology
Pregnancy
Young Adult
Gestational diabetes mellitus
Impaired glucose tolerance test
Leptin
Online AccessGet full text

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Abstract Abstract Objective The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (IGT). Materials and Methods This case-control study, at 28 weeks of gestation, measured serum concentration of fasting leptin, insulin, and homeostatic model assessment index in three groups, GDM, IGT, and normal control, and compared them with each other. Results The serum leptin level was significantly higher in women with GDM than in the two other groups ( p = 0.03). In women with GDM and IGT, leptin was significantly positively related with insulin and homeostatic model assessment index ( r = 0.221, p = 0.03) and ( r = 0.246, p = 0.03), respectively. In all of the participants, there was a significant correlation between leptin and body mass index before pregnancy ( r = 0.416, p = 0.001). Conclusion Our data showed that serum leptin level was higher in GDM and had a positive correlation with insulin resistance. Our findings suggest that high leptin levels might be a risk factor for GDM and IGT in pregnant women.
AbstractList Objective: The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (IGT). Materials and Methods: This case-control study, at 28 weeks of gestation, measured serum concentration of fasting leptin, insulin, and homeostatic model assessment index in three groups, GDM, IGT, and normal control, and compared them with each other. Results: The serum leptin level was significantly higher in women with GDM than in the two other groups (p=0.03). In women with GDM and IGT, leptin was significantly positively related with insulin and homeostatic model assessment index (r=0.221, p=0.03) and (r=0.246, p=0.03), respectively. In all of the participants, there was a significant correlation between leptin and body mass index before pregnancy (r=0.416, p=0.001). Conclusion: Our data showed that serum leptin level was higher in GDM and had a positive correlation with insulin resistance. Our findings suggest that high leptin levels might be a risk factor for GDM and IGT in pregnant women.
The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (IGT). This case-control study, at 28 weeks of gestation, measured serum concentration of fasting leptin, insulin, and homeostatic model assessment index in three groups, GDM, IGT, and normal control, and compared them with each other. The serum leptin level was significantly higher in women with GDM than in the two other groups ( p = 0.03). In women with GDM and IGT, leptin was significantly positively related with insulin and homeostatic model assessment index ( r = 0.221, p = 0.03) and ( r = 0.246, p = 0.03), respectively. In all of the participants, there was a significant correlation between leptin and body mass index before pregnancy ( r = 0.416, p = 0.001). Our data showed that serum leptin level was higher in GDM and had a positive correlation with insulin resistance. Our findings suggest that high leptin levels might be a risk factor for GDM and IGT in pregnant women.
Abstract Objective The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (IGT). Materials and Methods This case-control study, at 28 weeks of gestation, measured serum concentration of fasting leptin, insulin, and homeostatic model assessment index in three groups, GDM, IGT, and normal control, and compared them with each other. Results The serum leptin level was significantly higher in women with GDM than in the two other groups ( p = 0.03). In women with GDM and IGT, leptin was significantly positively related with insulin and homeostatic model assessment index ( r = 0.221, p = 0.03) and ( r = 0.246, p = 0.03), respectively. In all of the participants, there was a significant correlation between leptin and body mass index before pregnancy ( r = 0.416, p = 0.001). Conclusion Our data showed that serum leptin level was higher in GDM and had a positive correlation with insulin resistance. Our findings suggest that high leptin levels might be a risk factor for GDM and IGT in pregnant women.
The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (IGT). This case-control study, at 28 weeks of gestation, measured serum concentration of fasting leptin, insulin, and homeostatic model assessment index in three groups, GDM, IGT, and normal control, and compared them with each other. The serum leptin level was significantly higher in women with GDM than in the two other groups (p=0.03). In women with GDM and IGT, leptin was significantly positively related with insulin and homeostatic model assessment index (r=0.221, p=0.03) and (r=0.246, p=0.03), respectively. In all of the participants, there was a significant correlation between leptin and body mass index before pregnancy (r=0.416, p=0.001). Our data showed that serum leptin level was higher in GDM and had a positive correlation with insulin resistance. Our findings suggest that high leptin levels might be a risk factor for GDM and IGT in pregnant women.
Author Mojibian, Mahdieh
Rashidi, Maryam
Soheilykhah, Sedigheh
Hadinedoushan, Hossein
Rahimi-Saghand, Soodabeh
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Issue 2
Keywords Gestational diabetes mellitus
Impaired glucose tolerance test
Leptin
Language English
License http://www.elsevier.com/open-access/userlicense/1.0
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Snippet Abstract Objective The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational...
The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes mellitus...
Objective: The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes...
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SubjectTerms Adult
Body Mass Index
Case-Control Studies
Diabetes, Gestational - blood
Female
Gestational diabetes mellitus
Glucose Tolerance Test
Humans
Impaired glucose tolerance test
Insulin - blood
Insulin Resistance
Internal Medicine
Leptin
Leptin - blood
Obstetrics and Gynecology
Pregnancy
Young Adult
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Title Maternal serum leptin concentration in gestational diabetes
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