Maternal serum leptin concentration in gestational diabetes

Abstract Objective The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (IGT). Materials and Methods This case-control study, at 28 weeks of gestati...

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Published inTaiwanese journal of obstetrics & gynecology Vol. 50; no. 2; pp. 149 - 153
Main Authors Soheilykhah, Sedigheh, Mojibian, Mahdieh, Rahimi-Saghand, Soodabeh, Rashidi, Maryam, Hadinedoushan, Hossein
Format Journal Article
LanguageEnglish
Published China (Republic : 1949- ) Elsevier B.V 01.06.2011
Elsevier
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Summary:Abstract Objective The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (IGT). Materials and Methods This case-control study, at 28 weeks of gestation, measured serum concentration of fasting leptin, insulin, and homeostatic model assessment index in three groups, GDM, IGT, and normal control, and compared them with each other. Results The serum leptin level was significantly higher in women with GDM than in the two other groups ( p = 0.03). In women with GDM and IGT, leptin was significantly positively related with insulin and homeostatic model assessment index ( r = 0.221, p = 0.03) and ( r = 0.246, p = 0.03), respectively. In all of the participants, there was a significant correlation between leptin and body mass index before pregnancy ( r = 0.416, p = 0.001). Conclusion Our data showed that serum leptin level was higher in GDM and had a positive correlation with insulin resistance. Our findings suggest that high leptin levels might be a risk factor for GDM and IGT in pregnant women.
ISSN:1028-4559
1875-6263
DOI:10.1016/j.tjog.2011.01.034