Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3

• Published in: Experimental cell research Vol. 329; no. 1; pp. 18 - 25
• Main Authors: Beck, Carole, Robert, Isabelle, Reina-San-Martin, Bernardo, Schreiber, Valérie, Dantzer, Françoise
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.11.2014; Elsevier BV; Elsevier
• Subjects: Animals; Biochemistry, Molecular Biology; Cellular biology; DNA; DNA - genetics; DNA Damage; DNA Damage - genetics; DNA Repair; Enzymes; Genomics; Homologous recombination; Humans; Life Sciences; Non homologous end joining; Poly(ADP-ribose) Polymerases; Poly(ADP-ribose) Polymerases - metabolism; Proteins; Poly(ADP-ribose) polymerases; Non homologous end joining; DNA repair; Homologous recombination

Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins catalysed by Poly(ADP-ribose) polymerases (PARP). A wealth of recent advances in the biochemical and functional characterization of the DNA-dependent PARP family members have highlighted their key contribution in th...