Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity

• Published in: Journal of personalized medicine Vol. 13; no. 10; p. 1500
• Main Authors: Bairqdar, Ahmad, Shakhtshneider, Elena, Ivanoshchuk, Dinara, Mikhailova, Svetlana, Kashtanova, Elena, Shramko, Viktoriya, Polonskaya, Yana, Ragino, Yuliya
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2023; MDPI
• Subjects: Abdomen; abdominal obesity; Adipocytes; ADIPOQ; Cardiovascular disease; Cholesterol; Clopidogrel; Electrocardiography; Ethnicity; FTO; Genes; Genetic aspects; Genomics; GHRL; GLP1R; Glucose; High density lipoprotein; Maternity & paternity leaves; Next-generation sequencing; Obesity; obesity-associated genes; Phenotypes; Precision medicine; Preventive medicine; Questionnaires; Teenagers; Triglycerides; Type 2 diabetes; Womens health; Young adults; Youth; Japan; China; Finland; Russia; United States > US; Germany
• ISSN: 2075-4426; 2075-4426
• DOI: 10.3390/jpm13101500

The increase in the prevalence of overweight, obesity and associated diseases is a serious problem. The aim of the study was to identify rare variants in obesity-associated genes in young adults with abdominal obesity in our population and to analyze information about these variants in other populations. Targeted high-throughput sequencing of obesity-associated genes was performed (203 young adults with an abdominal obesity phenotype). In our study, all of the 203 young adults with abdominal obesity had some rare variant in the genes associated with obesity. The widest range of rare and common variants was presented in ADIPOQ, FTO, GLP1R, GHRL, and INS genes. The use of targeted sequencing and clinical criteria makes it possible to identify carriers of rare clinically significant variants in a wide range of obesity-associated genes and to investigate their influence on phenotypic manifestations of abdominal obesity.