Morphological Changes in Rat Hippocampus after Brain Injury

• Published in: Bulletin of experimental biology and medicine Vol. 152; no. 4; pp. 509 - 512
• Main Authors: Sokolova, I. B., Gilerovich, E. G., Pavlichenko, N. N., Polyntsev, D. G.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2012; Springer; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Brain; Brain architecture; Brain Injuries - pathology; Brain Injuries - therapy; Brain injury; Cell Biology; Cell culture; Cerebrum - injuries; Cerebrum - pathology; Cortex; Cortex (somatosensory); Disease Models, Animal; Hippocampus; Hippocampus - ultrastructure; Histocytochemistry; Injections, Intravenous; Injections, Intraventricular; Injuries; Internal Medicine; Intravenous administration; Laboratory Medicine; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - physiology; Motor Cortex - injuries; Motor Cortex - pathology; Neurons; Neurons - pathology; Neurons - ultrastructure; Pathology; Physiological aspects; Rats; Rats, Wistar; Surgery; Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine); Transplantation; hippocampus; mesenchymal stem cells; sensorimotor cortex ablation
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-012-1564-4

We performed morphological analysis of the structure of rat hippocampus after ablation of the left sensorimotor cortex. Four experimental groups were formed: two control groups (intravenous and intracerebral injections of the culture medium) and two experimental groups (intravenous and intracerebral transplantation of MSC). Ten weeks after surgery, disturbed cytoarchitectonics and great number of dead neurons were found in all zones of the hippocampus in animals of the control groups. In animals receiving cell therapy, no pathological changes in the structure of the hippocampus were found: hyperchromatic neurons were absent and the cells had regular shape and closely adjoined to each other.