New phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain Stachybotrys sp. f23793

• Published in: Bioscience, biotechnology, and biochemistry Vol. 84; no. 8; pp. 1570 - 1575
• Main Authors: Kawahara, Teppei, Itoh, Masashi, Izumikawa, Miho, Kagaya, Noritaka, Sakata, Noriaki, Tsuchida, Toshio, Shin-ya, Kazuo
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.08.2020; Oxford University Press
• Subjects: Cell Line, Tumor; Cell Survival - drug effects; Humans; Micrococcus luteus - drug effects; Micrococcus luteus - growth & development; phenylspirodrimane; Polycyclic Sesquiterpenes - chemistry; Polycyclic Sesquiterpenes - isolation & purification; Soil Microbiology; Spiro Compounds - chemistry; Spiro Compounds - isolation & purification; stachybotrin; Stachybotrys; Stachybotrys - chemistry; Stachybotrys - isolation & purification; phenylspirodrimane; stachybotrin; Stachybotrys
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1080/09168451.2020.1757402

Chemical screening of culture medium from the soil fungus Stachybotrys sp. resulted in the isolation of the three new phenylspirodrimanes MBJ-0030 (1), MBJ-0031 (2) and MBJ-0032 (3). Their structures were determined by detailed analysis of spectroscopic data. The absolute configurations of 1-3 were determined by modified Mosher's and Marfey's methods. In addition, cytotoxic and antimicrobial evaluations of the compounds were conducted. The structure of new phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain Stachybotrys sp. f23793.