DNA Immunization for HIV Vaccine Development

DNA vaccination has been studied in the last 20 years for HIV vaccine research. Significant experience has been accumulated in vector design, antigen optimization, delivery approaches and the use of DNA immunization as part of a prime-boost HIV vaccination strategy. Key historical data and future ou...

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Bibliographic Details
Published inVaccines Vol. 2; no. 1; pp. 138 - 159
Main Authors Chen, Yuxin, Wang, Shixia, Lu, Shan
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 25.02.2014
MDPI
Subjects
Acquired immune deficiency syndrome
AIDS
Deoxyribonucleic acid
DNA
DNA immunization
HIV
HIV-1
Human immunodeficiency virus
Immunization
Review
vaccine
Vaccines
HIV-1
AIDS
vaccine
DNA immunization
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Summary:DNA vaccination has been studied in the last 20 years for HIV vaccine research. Significant experience has been accumulated in vector design, antigen optimization, delivery approaches and the use of DNA immunization as part of a prime-boost HIV vaccination strategy. Key historical data and future outlook are presented. With better understanding on the potential of DNA immunization and recent progress in HIV vaccine research, it is anticipated that DNA immunization will play a more significant role in the future of HIV vaccine development.
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ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines2010138