Role of Macrophage Colony-Stimulating Factor for Staphylococcal Infection in the Oral Cavity

• Published in: Journal of clinical medicine Vol. 12; no. 18; p. 5825
• Main Authors: Senpuku, Hidenobu, Yoshimura, Kazuhisa, Takai, Hideki, Maruoka, Yutaka, Yamashita, Erika, Tominaga, Akira, Ogata, Yorimasa
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 07.09.2023; MDPI
• Subjects: Aged; Antiretroviral drugs; Antiviral agents; Bacteria; Bacteriology; Clinical medicine; Coronaviruses; COVID-19; Development and progression; Diagnosis; Disease susceptibility; Gum disease; Health aspects; Hepatitis; Highly active antiretroviral therapy; HIV; HIV (Viruses); HIV patients; Hospitals; Human immunodeficiency virus; Infection; Infectious diseases; Macrophage colony stimulating factor; Macrophages; Measurement; Mediation; Medical research; Medicine, Experimental; Microorganisms; Older people; Pathogens; Periodontal disease; Periodontics; Physiological aspects; Pneumonia; Risk factors; Salivary diagnostics; Staphylococcal infections; Staphylococcus infections; Streptococcus infections; Viral infections; Japan
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12185825

Objective: There are few valid indicators of oral infection owing to the complexity of pathogenic factors in oral diseases. Salivary markers are very useful for scrutinizing the symptoms of disease. To provide a reliable and useful predictive indicator of infection for opportunistic pathogens in individuals with compromised immune systems, such as those with periodontal diseases and Human Immunodeficiency Virus (HIV), this study examines opportunistic pathogens such as C. albicans and staphylococci and macrophage colony-stimulating factor (M-CSF) and CA125/MUC16 in saliva. The aim was to explore the correlations investigated among these factors. Methods: Samples were divided into two groups (based on patient sex, the absence and presence of dentures in elderly, or HIV-positive patients and healthy subjects), and the correlation was analyzed in two groups of elderly patients with periodontal disease (64.5 ± 11.2 years old) and HIV-infected patients (41.9 ± 8.4 years old). Healthy subjects (33.8 ± 9.1 years old) were also analyzed as a control. Levels of C. albicans, staphylococci, and M-CSF, which is an immunological factor for the differentiation of macrophage, and CA125/MUC16, which provides a protective lubricating barrier against infection, were investigated. Results: A significant and positive correlation between the levels of M-CSF and staphylococci was found in elderly individuals and HIV-positive patients treated with antiretroviral therapy. A significant and positive correlation between the levels of M-CSF and CD125/MUC16 was also found in both patients. These correlations were enhanced in both patients as compared with healthy subjects. Conclusion: Salivary M-CSF might be useful as a new indicator of opportunistic infection caused by staphylococci and a defense against infection in immunocompromised hosts.