Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f

• Published in: Phytochemistry (Oxford) Vol. 67; no. 3; pp. 302 - 306
• Main Authors: Ngouela, Silvère, Lenta, Bruno Ndjakou, Noungoue, Diderot Tchamo, Ngoupayo, Joseph, Boyom, Fabrice Fekam, Tsamo, Etienne, Gut, Jiri, Rosenthal, Philip J., Connolly, Joseph D.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.02.2006; Elsevier
• Subjects: Animals; Anti-plasmodial; antimalarials; Antimalarials - chemistry; Antimalarials - isolation & purification; Antimalarials - pharmacology; Antioxidant; antioxidants; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Biochemistry & Molecular Biology; Biological and medical sciences; Chemical constitution; chemical structure; Clusiaceae; Clusiaceae - chemistry; Clusiaceae - embryology; free radical scavenging activity; Fundamental and applied biological sciences. Psychology; gaboxanthone; General pharmacology; Life Sciences & Biomedicine; Medical sciences; Oleanolic Acid - chemistry; Oleanolic Acid - isolation & purification; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; phytochemicals; plant biochemistry; Plant physiology and development; Plant Sciences; Plasmodium falciparum; Plasmodium falciparum - drug effects; Science & Technology; Seed shells; seeds; Seeds - chemistry; spectral analysis; stereochemistry; Symphonia globulifera; Xanthones; Xanthones - chemistry; Xanthones - isolation & purification; Xanthones - pharmacology; Seed shells; Plasmodium falciparum; Xanthones; Symphonia globulifera; Antioxidant; Anti-plasmodial; anti-plasmodial; antioxidant; POTENTIATION; ERYTHROCYTES; xanthones; FALCIPARUM; ANTIMALARIAL ACTIVITY; AGENTS; seed shells; Xanthone; Seeds; Molecular structure; Pharmacognosy; Guttiferae; Citrate; Biological activity; Caffeic acid; Dicotyledones; Angiospermae; Plant origin; Phenols; Parasiticide; Isolation; Spermatophyta

HMBC correlation of compound 1 which demonstrated an interesting anti-plasmodial activity (3.53 μM). A xanthone derivative, named gaboxanthone ( 1), has been isolated from the seed shells of Symphonia globulifera, together with known compounds, symphonin ( 2), globuliferin ( 3), guttiferone A ( 4),...