Baseline brain function in the preadolescents of the ABCD Study

• Published in: Nature neuroscience Vol. 24; no. 8; pp. 1176 - 1186
• Main Authors: Allgaier, N., Adise, S., Owens, M. M., Juliano, A. C., Dumas, J., Mackey, S., Laurent, J., Hagler, D. J., Cornejo, M. D., Agrawal, A., Aguinaldo, L., Avenevoli, S., Banich, M. T., Barch, D. M., Bloch, M., Bogdan, R., Breslin, F., Calhoun, V., Casey, B. J., Chang, L., Clark, D. B., Cloak, C., Constable, R. T., Constable, K., Corley, R., Coxe, S., Dagher, R. K., Dapretto, M., Delcarmen-Wiggins, R., Do, E. K., Dowling, G. J., Fair, D. A., Fan, C. C., Florsheim, P., Foxe, J. J., Freedman, E. G., Friedman, N. P., Glantz, M., Glaser, P., Godino, J., Gonzalez, R., Grant, S., Gray, K. M., Hawes, S., Heeringa, S., Heitzeg, M. M., Hettema, J. M., Hewitt, J. K., Heyser, C., Hoffman, E., Howlett, K., Huestis, M. A., Iacono, W. G., Irfanoglu, O., Isaiah, A., Jacobus, J., James, R., Jernigan, T., Kit, B., Kuperman, J., Laird, A. R., Larson, C., Luciana, M., Luna, B., Madden, P. A., Maes, H. H., Makowski, C., Mason, M. J., Matochik, J., Morgan, G., Mulford, C., Nagel, B. J., Neale, M. C., Noronha, A., Pariyadath, V., Pfefferbaum, D., Pierpaoli, C., Prescot, A., Rapuano, K. M., Renshaw, P. F., Rojas, P., Schirda, C., Schloesser, D., Schulenberg, J., Sheth, C., Speer, N., Squeglia, L. M., Sripada, C., Steinberg, J., Sutherland, M. T., Tanabe, J., Tapert, S. F., Tomko, R. L., Uban, K. A., Wilbur, A., Wing, D., Wolff-Hughes, D., Yang, R., Potter, A., Garavan, H. P.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2021; Nature Publishing Group
• Subjects: 631/378/1457; 631/378/1595; 631/378/1788; 631/378/2632; 631/378/2649; Activation analysis; Adolescent; Adolescent development; Adolescent Development - physiology; Adolescents; Adults; Age; Animal Genetics and Genomics; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Brain; Brain - physiology; Brain mapping; Brain research; Child; Child development; Children; Cognition in children; Cognitive ability; Female; Functional magnetic resonance imaging; Humans; Impulsive behavior; Inhibition (psychology); Magnetic Resonance Imaging; Male; Medical imaging; Memory; Mental task performance; Neurobiology; Neuroimaging; Neurosciences; Reference Values; Regions; Reinforcement; Resource; Short term memory; Teenagers; United States
• ISSN: 1097-6256; 1546-1726; 1546-1726
• DOI: 10.1038/s41593-021-00867-9

The Adolescent Brain Cognitive Development (ABCD) Study ® is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N  = 5,547), reward anticipation and receipt with a monetary incentive delay (MID) task ( N  = 6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task ( N  = 6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development. This paper reports activation patterns for fMRI tasks assessing response inhibition, working memory and reward processing obtained at baseline in the longitudinal ABCD Study, providing a reference for research into adolescent brain development.