Additional Benefit of Canakinumab on Proteinuria in a Case With Muckle-Wells Syndrome in Remission Under Anakinra

Periodic fever, increased acute phase reactants and serum amyloid A (SAA), hypoalbuminemia, edema and other disease features resolved completely as well, except hearing loss which needed a cochlear implant to be corrected. [...]a clinical and laboratory remission, the eventual goal of the treatment,...

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Bibliographic Details
Published inArchives of rheumatology Vol. 35; no. 1; pp. 149 - 150
Main Authors Ilgen, Ufuk, Kucuksahin, Orhan
Format Journal Article
LanguageEnglish
Published Istanbul Turkish League Against Rheumatism 01.03.2020
Prof Sebnem Ataman, President Turkish League Against Rheumatism
Subjects
Amyloidosis
Arthritis
Authorship
Biopsy
Cytokines
Hearing loss
Kidney diseases
Laboratories
Letter
Monoclonal antibodies
Remission (Medicine)
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Summary:Periodic fever, increased acute phase reactants and serum amyloid A (SAA), hypoalbuminemia, edema and other disease features resolved completely as well, except hearing loss which needed a cochlear implant to be corrected. [...]a clinical and laboratory remission, the eventual goal of the treatment, was achieved with anakinra. A repeat kidney biopsy was not performed in the presented case due to the risk of bleeding, absence of any benefit for the management, and the previous reports of persistence and even progression of amyloidosis despite the improvement in inflammatory disease features and proteinuria.5 In conclusion, canakinumab seems to be more efficacious in MWS-related amyloidosis even in those who would achieve remission with anakinra.
ISSN:2148-5046
1309-0291
2618-6500
1309-0283
DOI:10.5606/ArchRheumatol.2020.7378