Expert consensus on a multidisciplinary approach for the management of multiple myeloma-related bone disease

• Published in: Cancer pathogenesis and therapy Vol. 3; no. 4; pp. 280 - 292
• Main Authors: Wang, Yutong, Xu, Qiming, Li, Yuan, Su, Yongbin, Wang, Ling, Wang, Xiaoquan, Ge, Jian, Jing, Hongmei, Guo, Yuxing, Chen, Yalin, Li, Xianan, Zhuang, Jun-ling, Tan, Jing, Wang, Xiaobo, Zhong, Liye, Luo, Jun, Zhao, Peng, Fan, Shengjin, Ren, Jinhai, Yang, Haiping, Mei, Heng, Sun, Chunyan, Li, Chunrui, Sun, Xuemei, Lu, Xuechun, Gao, Guangxun, Zhou, Zeping, Pan, Yaozhu, Sun, Ying, Hong, Zhang, Liu, Zhiqiang, Ma, Yanping, Wang, Yi, Sun, Wei, Hou, Jian, Mi, Jianqing, Chen, Wenming, Huang, Xiaobing, Li, Bingzong, Fu, Rong, Shi, Jumei, Ran, Xuehong, Zhou, Fuling, He, Aili, Mao, Min, Cai, Zhen, Li, Nan, Xu, Meng, Yan, Xiaojing, Yang, Wei, An, Gang, Gong, Lihua, Sun, Lichao, Li, Zhihong, Liu, Tang, He, Yanjuan, Yin, Junqiang, Liu, Yao, Liu, Weifeng, Bao, Li
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2025; Elsevier
• Subjects: Bone disease; Consensus and Guidelines; Diphosphonates; Multiple myeloma; Orthopedics; Quality of life; Recommendation; Therapeutic effect; Diphosphonates; Therapeutic effect; Orthopedics; Multiple myeloma; Bone disease; Recommendation; Quality of life
• ISSN: 2949-7132; 2097-2563; 2949-7132
• DOI: 10.1016/j.cpt.2024.12.002

This consensus on multiple myeloma-related bone diseases (MBDs) underscores the importance of a multidisciplinary approach that encompasses hematology, radiology, orthopedics, and additional specialties to tackle its intricate challenges. MBD, a prevalent and debilitating complication of multiple myeloma, leads to bone pain, fractures, and skeletal-related events (SREs), which profoundly impact patients’ quality of life. The guidelines offer a thorough framework for diagnosis, treatment, and continual assessment, emphasizing early detection and consistent monitoring using imaging techniques such as positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI). Treatment strategies prioritize the careful application of anti-myeloma agents, bisphosphonates, and denosumab to minimize bone loss and decrease SRE risk, complemented by surgical and radiotherapy interventions for structural or pain-related issues. Supportive care measures, including pain management, rehabilitation, nutritional support, and dental evaluations, play a crucial role in enhancing patient outcomes and preserving quality of life. This consensus advocates a standardized, evidence-based approach to managing MBD, ensuring comprehensive and coordinated care for patients. •A multidisciplinary approach is essential for managing multiple myeloma-related bone disease (MBD).•MBD in myeloma causes pain, fractures, and skeletal-related events (SREs), lowering patients' quality of life.•Guidelines stress early detection and monitoring via positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI).•Treatments focus on anti-myeloma agents, bisphosphonates, and denosumab.•Supportive care, including pain control and rehab, improves patient outcomes.