Antibacterial and cytotoxic xanthones from the roots of Cratoxylum formosum

• Published in: Phytochemistry (Oxford) Vol. 67; no. 7; pp. 723 - 727
• Main Authors: Boonsri, Sompong, Karalai, Chatchanok, Ponglimanont, Chanita, Kanjana-opas, Akkharawit, Chantrapromma, Kan
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.04.2006; Elsevier
• Subjects: Anthraquinones - chemistry; Anthraquinones - isolation & purification; Anthraquinones - pharmacology; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibacterial activity; antibacterial properties; anticarcinogenic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biochemistry & Molecular Biology; Biological and medical sciences; Chemical constitution; chemical structure; Clusiaceae; Clusiaceae - chemistry; Cratoxylum formosum; cultured cells; Cytotoxicity; Formoxanthone; Fundamental and applied biological sciences. Psychology; Fungi - drug effects; General pharmacology; Guttiferae; Humans; Life Sciences & Biomedicine; Medical sciences; medicinal plants; Microbial Sensitivity Tests; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; phytochemicals; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant physiology and development; Plant Roots - chemistry; Plant Sciences; Plants, Medicinal; Science & Technology; spectral analysis; Toxicity Tests; Tumor Cells, Cultured; xanthones; Xanthones - chemistry; Xanthones - isolation & purification; Xanthones - pharmacology; Antibacterial activity; Cytotoxicity; Cratoxylum formosum; Formoxanthone; Guttiferae; antibacterial activity; FRUITS; ESTERS; PRENYLATED XANTHONES; formoxanthone; cytotoxicity; Characterization; Xanthone; Anthraquinone; Root; Molecular structure; Isolation
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2006.01.007

Formoxanthone A–C ( 1–3) together with six known compounds were isolated from the hexane extract of the roots of Cratoxylum formosum. In addition, antibacterial and cytotoxic activities of the isolates were also evaluated. Chemical investigation of the roots of Cratoxylum formosum has resulted in the isolation and characterization of xanthones: three new, named formoxanthone A–C and three known together with three known anthraquinones. Their structures were established on the basis of analysis of spectroscopic evidence. In addition, antibacterial and cytotoxic activities of the isolates were also evaluated.