Stiffness-distortion sarcomere model for muscle simulation
Departments of 1 Veterinary and Comparative Anatomy, Pharmacology and Physiology and 2 Biological Systems Engineering, Washington State University, Pullman, Washington 99164; 3 Department of Physics, Division of Biophysics, Moscow State University, Moscow; and 4 Institute of Theoretical and Expe...
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Published in | Journal of applied physiology (1985) Vol. 87; no. 5; pp. 1861 - 1876 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Am Physiological Soc
01.11.1999
American Physiological Society |
Subjects | |
Online Access | Get full text |
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Summary: | Departments of 1 Veterinary and Comparative Anatomy,
Pharmacology and Physiology and 2 Biological Systems
Engineering, Washington State University, Pullman, Washington 99164;
3 Department of Physics, Division of Biophysics, Moscow
State University, Moscow; and 4 Institute
of Theoretical and Experimental Biophysics, Russian Academy of
Sciences, Puschino, Russia
A relatively simple method is presented for incorporating
cross-bridge mechanisms into a muscle model. The method is based on
representing force in a half sarcomere as the product of the stiffness
of all parallel cross bridges and their average distortion. Differential equations for sarcomeric stiffness are derived from a
three-state kinetic scheme for the cross-bridge cycle. Differential equations for average distortion are derived from a distortional balance that accounts for distortion entering and leaving due to
cross-bridge cycling and for distortion imposed by shearing motion
between thick and thin filaments. The distortion equations are unique
and enable sarcomere mechanodynamics to be described by only a few
ordinary differential equations. Model predictions of small-amplitude
step and sinusoidal responses agreed well with previously described
experimental results and allowed unique interpretations to be made of
various response components. Similarly good results were obtained for
model reproductions of force-velocity and large-amplitude step and ramp
responses. The model allowed reasonable predictions of contractile
behavior by taking into account what is understood to be basic muscle
contractile mechanisms.
mathematical model; muscle mechanics; muscle cross bridge; muscle
contraction |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 8750-7587 1522-1601 |
DOI: | 10.1152/jappl.1999.87.5.1861 |