Amyloid-β associated volume loss occurs only in the presence of phospho-tau

The relationship between neurodegeneration and the 2 hallmark proteins of Alzheimer's disease, amyloid‐β (Aβ) and tau, is still unclear. Here, we examined 286 nondemented participants (107 cognitively normal older adults and 179 memory impaired individuals) who underwent longitudinal magnetic r...

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Published inAnnals of neurology Vol. 70; no. 4; pp. 657 - 661
Main Authors Desikan, Rahul S., McEvoy, Linda K., Thompson, Wesley K., Holland, Dominic, Roddey, J. Cooper, Blennow, Kaj, Aisen, Paul S., Brewer, James B., Hyman, Bradley T., Dale, Anders M.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2011
Wiley-Liss
Subjects
80 and over
Aged
Aged, 80 and over
Amnesia
Amnesia - cerebrospinal fluid
Amnesia - pathology
Amyloid beta-Peptides
Amyloid beta-Peptides - cerebrospinal fluid
Atrophy
Biological and medical sciences
Cerebral Cortex
Cerebral Cortex - pathology
cerebrospinal fluid
Cognitive Dysfunction - cerebrospinal fluid
Cognitive Dysfunction - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Humans
Longitudinal Studies
Male
Medical sciences
Mild Cognitive Impairment
Neurology
pathology
Peptide Fragments
Peptide Fragments - cerebrospinal fluid
Psychiatry
Psykiatri
tau Proteins
tau Proteins - cerebrospinal fluid
Nervous system diseases
Amyloid
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Summary:The relationship between neurodegeneration and the 2 hallmark proteins of Alzheimer's disease, amyloid‐β (Aβ) and tau, is still unclear. Here, we examined 286 nondemented participants (107 cognitively normal older adults and 179 memory impaired individuals) who underwent longitudinal magnetic resonance (MR) imaging and lumbar puncture. Using mixed effects models, we investigated the relationship between longitudinal entorhinal cortex atrophy rate, cerebrospinal fluid (CSF) p‐tau181p and CSF Aβ1–42. We found a significant relationship between elevated entorhinal cortex atrophy rate and decreased CSF Aβ1–42 only with elevated CSF p‐tau181p. Our findings indicate that Aβ‐associated volume loss occurs only in the presence of phospho‐tau in humans at risk for dementia. Ann Neurol 2011
Bibliography:istex:5A61294777A93211BE2CBE186500FFCA7A687D7D
ArticleID:ANA22509
ark:/67375/WNG-GWFRL8LX-5
Information about the Alzheimer's Disease Neuroimaging Initiative is listed in the Appendix on page xx.
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Data used in the preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (www.loni.ucla.edu/ADNI). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. ADNI investigators include (complete listing available at http://adni.loni.ucla.edu/wp-content/uploads/how_to_apply/ADNI_Authorship_List.pdf
ISSN:0364-5134
1531-8249
1531-8249
DOI:10.1002/ana.22509