Spinal 5-HT7 receptors and protein kinase A constrain intermittent hypoxia-induced phrenic long-term facilitation

• Published in: Neuroscience Vol. 250; pp. 632 - 643
• Main Authors: Hoffman, M.S, Mitchell, G.S
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 10.10.2013; Elsevier
• Subjects: Animals; Arterial Pressure - drug effects; Arterial Pressure - physiology; Biological and medical sciences; Blood Gas Analysis; Carbazoles - pharmacology; Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases - metabolism; Data Interpretation, Statistical; Enzyme Inhibitors - pharmacology; Fundamental and applied biological sciences. Psychology; Hypoglossal Nerve - physiology; hypoxia; Hypoxia - enzymology; Hypoxia - metabolism; Injections, Spinal; long-term facilitation; Long-Term Potentiation - physiology; Male; motor neuron; NADPH Oxidases - metabolism; Neurology; Phenols - pharmacology; phrenic; Phrenic Nerve - physiology; Pyrroles - pharmacology; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk - physiology; Receptors, G-Protein-Coupled - metabolism; Receptors, Serotonin - drug effects; Receptors, Serotonin - metabolism; respiratory control; respiratory plasticity; Serotonin Antagonists - pharmacology; Spinal Cord - drug effects; Spinal Cord - enzymology; Spinal Cord - metabolism; Sulfonamides - pharmacology; Vertebrates: nervous system and sense organs; NADPH; respiratory control; pMF; PETCO 2; end-tidal carbon dioxide partial pressures; analysis of variance; ANOVA; long-term facilitation; reactive oxygen species; phrenic; brain-derived neurotrophic factor; protein kinase A; AIH; hypoxia; phrenic long-term facilitation; BDNF; nicotinamide adenine dinucleotide phosphate; PKA; phrenic motor facilitation; respiratory plasticity; motor neuron; ROS; acute intermittent hypoxia; pLTF; MAP; mean arterial pressures; PETCO2; Oxygen; Plasticity; Environmental factor; Hypoxia; Motor neuron; 5-HT7 serotonin receptor; cAMP-dependent protein kinase; Long term; PETCO
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.06.068

Highlights • Spinal 5-HT7 receptor inhibition enhances pLTF after AIH. • Spinal PKA inhibition enhances pLTF. • Spinal PKA activation blunts pLTF. • 5-HT7 receptors constrain AIH-induced pLTF, acting via PKA.