Biological action of estrogen on the epididymis of prepubertal rhesus monkey

An estrogen binding protein has been demonstrated in the cytosol of the epididymis and caudal lobe of prostate of immature rhesus monkey. Scatchard plot analyses were linear, suggesting a single class of high affinity binding sites for the synthetic estrogen, R-2858 (Moxestrol) with a Kd of 5.88 X 1...

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Bibliographic Details
Published inAndrologia Vol. 17; no. 4; p. 339
Main Authors Kamal, N, Agarwal, A K, Jehan, Q, Setty, B S
Format Journal Article
LanguageEnglish
Published Germany 01.07.1985
Subjects
Animals
Binding Sites
Cytosol - metabolism
Epididymis - drug effects
Estradiol - pharmacology
Estrogens - pharmacology
Ethinyl Estradiol - analogs & derivatives
Ethinyl Estradiol - metabolism
Genitalia, Male - drug effects
Kinetics
Macaca mulatta
Male
N-Acetylneuraminic Acid
Organ Size
Prostate - metabolism
Sexual Maturation
Sialic Acids - analysis
Testosterone - pharmacology
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Summary:An estrogen binding protein has been demonstrated in the cytosol of the epididymis and caudal lobe of prostate of immature rhesus monkey. Scatchard plot analyses were linear, suggesting a single class of high affinity binding sites for the synthetic estrogen, R-2858 (Moxestrol) with a Kd of 5.88 X 10(-10) mol/l and a concentration of binding sites of 17.0 +/- 4.4 fmol/mg cytosol protein in the epididymis. In the prostate, the concentration of binding sites was 19.7 +/- 3.6 fmol/mg cytosol protein with a Kd of 5.42 X 10(-10) mol/l. In immature castrated monkeys, administration of estradiol dipropionate caused a significant increase in the weight, total protein and sialic acid content of the epididymis. This biological action of estrogen on the epididymis is presumably mediated via estrogen receptor.
ISSN:0303-4569
1439-0272
DOI:10.1111/j.1439-0272.1985.tb01016.x