Current trends in miRNAs and their relationship with oral squamous cell carcinoma

• Published in: Journal of oral pathology & medicine Vol. 41; no. 6; pp. 433 - 443
• Main Authors: Pérez-Sayáns, Mario, Pilar, Gayoso-Diz, Barros-Angueira, Francisco, Suárez-Peñaranda, José Manuel, Fernández, Alexia Conde, Gándara-Rey, José Manuel, García-García, Abel
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2012; Wiley
• Subjects: Apoptosis; Biological and medical sciences; Carcinogenesis; Carcinoma, Squamous Cell - genetics; Cell cycle; Differentiation; Drug Resistance, Multiple - genetics; Epigenesis, Genetic - genetics; epigenetics; Gene Expression Regulation, Neoplastic - genetics; Gene polymorphism; Genes, Tumor Suppressor; Humans; Medical sciences; micro RNA; MicroRNAs - genetics; miRNA; Mouth Neoplasms - genetics; mRNA; Multidrug resistance; non-coding RNA; Nucleotides; Oncogenes; Oncogenes - genetics; oral squamous cell carcinoma; Otorhinolaryngology. Stomatology; Polymorphism, Genetic - genetics; Post-transcription; tumor suppressor gene; Tumor suppressor genes; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Messenger RNA; Stomatology; micro RNA; oncogenes; Oral cavity disease; ENT; mRNA; Malignant tumor; Oral squamous cell carcinoma; Onc gene; Cancer; Tumor suppressor gene
• ISSN: 0904-2512; 1600-0714; 1600-0714
• DOI: 10.1111/j.1600-0714.2011.01121.x

J Oral Pathol Med (2012) 41: 433–443 A micro RNA (miRNA) is a single‐stranded endogenous, non‐coding RNA, with length ranging between 18 and 24 nucleotides and the ability of regulating the expression of other genes on a post‐transcriptional level by means of various processes, degradation or repression of target mRNA. miRNAs play a crucial role in regulating fundamental processes such as cell cycle, differentiation and apoptosis; thus, their deregulation can affect normal cell growth and development, and even participate in carcinogenesis. The goals of this paper are: to outline the formation and functions of miRNAs; to determine their role in oral squamous cell carcinoma; to analyze the different miRNAs described and their roles as oncogenes or tumor suppressor genes, depending on their overexpression or subexpression; to describe the different polymorphisms and epigenetic alterations identified; and to determine their role in multidrug resistance.