The Controversy of Using Insufficient Great Saphenous Veins in Coronary Artery Bypass Grafting: A Comparative Morphological Analysis of Healthy and Insufficient Veins Related to the Possibility of Using Them as a Graft

• Published in: Biomedicines Vol. 12; no. 3; p. 476
• Main Authors: Părău, Andrei Florin, Manzur, Andrei Raul, Mihaicuta, Stefan, Petrache, Ioan Adrian
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.02.2024; MDPI
• Subjects: Acute coronary syndromes; Bypass; Cardiovascular disease; Clinical outcomes; Coronary artery; Coronary artery bypass; coronary bypass; Coronary vessels; Health care; Heart surgery; Medical research; Medicine, Experimental; Morphology; Pathology; Physical characteristics; Smooth muscle; Statistical analysis; Surgeons; Surgery; Varicose veins; Vascularization; vein graft; Veins; venous wall morphology; Romania; coronary bypass; venous wall morphology; varicose veins; vein graft
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines12030476

Despite advancements in coronary artery bypass grafting (CABG), the optimal choice of graft material remains a subject of investigation. This study aimed to comprehensively analyze the morphological characteristics of varicose veins, exploring their potential utilization in CABG compared to healthy veins. The study included 178 patients, categorized into two groups based on healthy and varicose veins. Morphological parameters, including maximum venous diameter, wall thickness, and specific changes in tunica intima (TI), tunica media (TM), and tunica adventitia (TA), were analyzed through microscopic evaluation. Varicose veins exhibited a significantly larger maximum venous diameter ( = 0.0001) and increased wall thickness ( = 0.0001) compared to healthy veins. Although varicose veins showed thickening in TI and TM, the differences were not statistically significant. Notably, disorganized smooth muscle bundles were more prevalent in varicose veins ( = 0.001), suggesting potential wall weakness. The absence of vasa vasorum in TA was significantly higher in varicose veins ( = 0.050), influencing vascularization considerations. The comparative morphological microscopic analysis of the specimens of healthy and varicose veins reveals significant differences between the groups, which make the conclusion of this study to plead for avoiding the use of varicose veins as a graft.