EUS-FNA Diagnosis of a Metastatic Adult Granulosa Cell Tumor in the Stomach

• Published in: Laboratory medicine Vol. 53; no. 5; pp. 533 - 536
• Main Authors: Nikas, Ilias P, Sepsa, Athanasia, Kleidaradaki, Evangelia, Salla, Charitini
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.09.2022
• Subjects: Case Study; Health aspects; Immunohistochemistry; Inhibin; Medical diagnosis; Metastasis; Ovarian cancer; Ovaries; Ultrasonic imaging; Greece; cytology; neoplasm; immunohistochemistry; ovarian cancer; metastasis; cytopathology
• ISSN: 0007-5027; 1943-7730
• DOI: 10.1093/labmed/lmac024

Abstract Granulosa cell tumors are uncommon ovarian neoplasms, predominantly of the adult type (AGCT). In this report, we present a rare case of a patient with metastatic AGCT to the stomach diagnosed with endoscopic ultrasound–guided fine-needle aspiration (EUS-FNA). A 61-year-old woman without a history of AGCT underwent both a vaginal and an abdominal ultrasound that showed a solid and cystic ovarian mass along with a solid mass in the gastric antral wall. Subsequently, an EUS-FNA was performed to assess the gastric lesion. Cytologic findings showed high cellularity, and the groups of neoplastic cells invaded the muscle layer of the stomach. Notably, these cells formed Call-Exner bodies, whereas some nuclei exhibited nuclear grooves. Immunohistochemistry was performed, revealing positivity for α-inhibin, calretinin, and CD56 in the neoplastic cells, whereas chromogranin, synaptophysin, CD117, and DOG1 were negative. The combination of clinical presentation, radiology, cytomorphology, and immunohistochemistry could facilitate the diagnosis of metastatic AGCT and the management of such patients.