Functional Switching of GABAergic Synapses by Ryanodine Receptor Activation

The role of the ryanodine receptor (RyR) in modifiability of synapses made by the basket interneurons onto the hippocampal CA1 pyramidal cells was examined in rats. Associating single-cell RyR activation with postsynaptic depolarization increased intracellular free Ca2+concentrations and reversed th...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 97; no. 22; pp. 12300 - 12305
Main Authors Sun, Miao-Kun, Nelson, Thomas J., Alkon, Daniel L.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 24.10.2000
National Acad Sciences
National Academy of Sciences
The National Academy of Sciences
Subjects
Action potentials
Amplifiers
Animals
basket cells
bicarbonate
Biological Sciences
Brain
Depolarization
Electrodes
Excitatory Amino Acid Antagonists - pharmacology
gamma-Aminobutyric Acid - physiology
Hippocampus - cytology
Hippocampus - drug effects
Hippocampus - physiology
Interneurons
Kynurenic Acid - pharmacology
Male
Neurology
Neurons
Neurons - drug effects
Neurons - physiology
Neuroscience
Pyramidal cells
Rats
Rats, Sprague-Dawley
Receptors
Rodents
Ryanodine Receptor Calcium Release Channel - drug effects
Ryanodine Receptor Calcium Release Channel - physiology
Synapses
Synapses - drug effects
Synapses - physiology
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Summary:The role of the ryanodine receptor (RyR) in modifiability of synapses made by the basket interneurons onto the hippocampal CA1 pyramidal cells was examined in rats. Associating single-cell RyR activation with postsynaptic depolarization increased intracellular free Ca2+concentrations and reversed the basket interneuron-CA1 inhibitory postsynaptic potential into an excitatory postsynaptic potential. This synaptic transformation was accompanied by a shift of the reversal potential from that of chloride toward that of bicarbonate. This inhibitory postsynaptic potential-excitatory postsynaptic potential transformation was prevented by blocking RyR or carbonic anhydrase. Associated postsynaptic depolarization and RyR activation, therefore, changes GABAergic synapses from excitation filters to amplifier and, thereby, shapes information flow through the hippocampal network.
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Communicated by Bernhard Witkop, National Institutes of Health, Bethesda, MD
To whom reprint requests should be addressed at: Laboratory of Adaptive Systems, National Institute of Neurological Disorders and Stroke/National Institutes of Health, Building 36, Room 4A24, 36 Convent Drive, Bethesda, MD 20892. E-mail: mksun@codon.nih.gov.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.210396697