Regulation of Th2 Cell Immunity by Dendritic Cells

Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to p...

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Bibliographic Details
Published inImmune network Vol. 16; no. 1; pp. 1 - 12
Main Authors Na, Hyeongjin, Cho, Minkyoung, Chung, Yeonseok
Format Journal Article
LanguageEnglish
Published Korea (South) 대한면역학회 01.02.2016
The Korean Association of Immunologists
Subjects
Review
면역학
Dendritic cell
Th2 cell
Allergic inflammation
CD301b
PDL2
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Summary:Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell lineage commitment. In this regard, immune cells other than dendritic cells, such as basophils and innate lymphoid cells, have been suggested as Th2 cell inducers. More recently, multiple independent researchers have shown that specialized subsets of dendritic cells mediate Th2 cell responses. This review will discuss the current understanding related to the regulation of Th2 cell responses by dendritic cells and other immune cells.
Bibliography:ObjectType-Article-2
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G704-001562.2016.16.1.006
http://dx.doi.org/10.4110/in.2016.16.1.
ISSN:1598-2629
2092-6685
DOI:10.4110/in.2016.16.1.1