Influence of Human Immunodeficiency Virus Type 1 Infection on Acute Hepatitis A Virus Infection

• Published in: Clinical infectious diseases Vol. 34; no. 3; pp. 379 - 385
• Main Authors: Ida, Setsuko, Tachikawa, Natsuo, Nakajima, Aya, Daikoku, Manabu, Yano, Michitami, Kikuchi, Yoshimi, Yasuoka, Akira, Kimura, Satoshi, Oka, Shinichi
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.02.2002; University of Chicago Press
• Subjects: Acute Disease; Adult; Alanine Transaminase - metabolism; Aspartate Aminotransferases - metabolism; Biological and medical sciences; Excretion; Female; Hepatitis A; Hepatitis A - etiology; Hepatitis A virus; Hepatitis A virus - genetics; Hepatitis A virus - physiology; HIV 1; HIV Infections - complications; HIV Infections - virology; HIV-1 - physiology; HIV/AIDS; Homosexuality; Human viral diseases; Humans; Infections; Infectious diseases; Male; Male homosexuality; Medical sciences; Middle Aged; Polymerase Chain Reaction; Serologic Tests; Symptoms; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral hepatitis; Viral Load; Viremia; Viremia - virology; Viruses; Human; Immunopathology; Mixed infection; Prognosis; HIV-1 virus; Acute; Retroviridae; Hepatic disease; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Viral hepatitis A; Viral disease; Risk factor; Digestive diseases; Evolution; Human immunodeficiency virus
• ISSN: 1058-4838; 1537-6591; 1537-6591
• DOI: 10.1086/338152

To assess the possible influence of human immunodeficiency virus type 1 (HIV-1) infection on the clinical course of acute hepatitis A virus (HAV) infection, 15 HIV-1-infected homosexual men and 15 non-HIV-infected age-matched subjects were compared. HAV load was higher in HIV-1-infected than in non-HIV-infected patients (P < .001). Duration of viremia in HIV-1-infected patients (median, 53 days) was significantly (P < .05) longer than in non-HIV-infected patients (median, 22 days). HIV-1-infected patients had lower elevations in alanine aminotransferase levels than did non-HIV-infected patients (P < .01) but had higher elevations in alkaline phosphatase levels than did non-HIV-infected patients (P < .001). Some HIV-1-infected patients still had HAV viremia when clinical symptoms had disappeared and alanine aminotransferase levels had returned to normal (60-90 days after the onset of symptoms). HIV-1 infection was associated with prolongation of HAV viremia, which might cause a long-lasting outbreak of HAV infection in HIV-1-infected homosexual men.