Amyloid $\beta $ Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage near the Alzheimer Locus

• Published in: Science (American Association for the Advancement of Science) Vol. 235; no. 4791; pp. 880 - 884
• Main Authors: Tanzi, Rudolph E., Gusella, James F., Watkins, Paul C., Gail A. P. Bruns, St George-Hyslop, Peter, Van Keuren, Margaret L., Patterson, David, Pagan, Susan, Kurnit, David M., Neve, Rachael L.
• Format: Journal Article
• Language: English
• Published: Washington, DC The American Association for the Advancement of Science 20.02.1987; American Association for the Advancement of Science
• Subjects: Alzheimer Disease - genetics; Alzheimer's disease; Amino Acid Sequence; Amino acids; Amyloid - genetics; Amyloidosis - genetics; Amyloids; Analysis; Biological and medical sciences; Brain - physiopathology; Chromosome Mapping; Chromosomes; Chromosomes, Human, Pair 21; Complementary DNA; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; DNA - genetics; Down Syndrome - genetics; Gene Expression Regulation; Genes; Genetic aspects; Genetic Linkage; Genetic loci; Genomics; Humans; Medical genetics; Medical sciences; Messenger RNA; Neurology; Oligonucleotide probes; RNA; RNA, Messenger - genetics; Tissue Distribution; Transcription, Genetic; Proteins; Nervous system diseases; Linkage; Messenger RNA; Complementary DNA; Gene; Alzheimer disease; Genetics; Amyloid; Degenerative disease; Locus; Geriatrics
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.2949367

The amyloid $\beta $ protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome. A complementary DNA for the $\beta $ protein suggests that it derives from a larger protein expressed in a variety of tissues. Overexpression of the gene in brain tissue from fetuses with Down syndrome (trisomy 21) can be explained by dosage since the locus encoding the $\beta $ protein maps to chromosome 21. Regional localization of this gene by both physical and genetic mapping places it in the vicinity of the genetic defect causing the inherited form of Alzheimer's disease.