Dynamic changes and clinical significance of serum S100B protein and glial fibrillary acidic protein in patients with delayed encephalopathy after acute carbon monoxide poisoning

• Published in: Pakistan journal of medical sciences Vol. 34; no. 4; pp. 945 - 949
• Main Authors: Di, Chong, Zeng, Yun, Mao, Jingyu, Shen, Zhengjie, Gu, Wenzhe
• Format: Journal Article
• Language: English
• Published: Pakistan Knowledge Bylanes 31.08.2018; AsiaNet Pakistan (Pvt) Ltd; Professional Medical Publications
• Subjects: Activities of daily living; Blood-brain barrier; Brain damage; Carbon monoxide; Carbon monoxide poisoning; Care and treatment; Clinical significance; Coma; Consciousness; Dementia; Encephalopathy; Enzyme-linked immunosorbent assay; Hospitalization; Hydrogen sulfide; Medical research; Migraine; Nervous system; Original; Oxygen therapy; Proteins; Studies; Trauma; Traumatic brain injury; Acute carbon monoxide poisoning; Delayed encephalopathy; S100B; Glial fibrillary acidic protein
• ISSN: 1682-024X; 1681-715X
• DOI: 10.12669/pjms.344.15363

To study the dynamic changes and clinical significance of serum S100B protein and glial fibrillary acidic protein (GFAP) in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). This study was conducted among DEACMP patients who were hospitalized from November 2014 to February 2016. Serum levels of S100B and GFAP in 66 DEACMP patients were measured by ELISA. Changes in patient states were examined dynamically using activities of daily living (ADL) scale, information-memory-concentration test (IMCT) and Hasegawa's dementia scale (HDS), and compared with those of 64 patients without DE after ACMP. Serum S100B [(0.59 ± 0.11) ng/ml] and GFAP [(227.67 ± 12.43) ng/ml] levels of DEACMP group in acute phase were significantly higher than those of ACMP group [(0.48 ± 0.10) ng/ml and (178.91 ± 11.47) ng/ml] and DEACMP group in recovery phase [(0.49 ± 0.12) ng/ml and (179.54 ± 12.32) ng/ml] (all P<0.05). Serum S100B and GFAP levels of DEACMP group were significantly correlated in both acute and recovery phases (r=0.432 in acute phase, P=0.007; r=0.378 in recovery phase, P=0.034). ADL, HDS and IMCT scores of DEACMP group in acute phase were (45.12 ± 3.12), (7.98 ± 1.02) and (9.61 ± 1.41) points respectively, which were significantly different from those of recovery phase [(33.25 ± 3.09), (16.13 ± 1.17) and (19.54 ± 1.43) points respectively] (P<0.05). DEACMP was accompanied by secondary brain injury, for which glial activation may be important. Serum S100B and GFAP levels may be related to prognosis.